Addition of strength training modifies the aerobic exercise inflammatory response in heart failure patients – Comments on the underlying pathophysiology

Aim: The present study investigates the effect of Strength Training addition in a High Intensity Interval (HIIT) program, on inflammatory profile chronic heart failure (CHF) patients.
 Materials and Methods: Forty-six CHF patients were randomized into two different exercise rehabilitation groups. A patient group (control) performed HIIT another Combined (HIIT strength training) Exercise (COM) for three- month period. Before after rehabilitation, all maximal cardiopulmonary testing (CPET). Microcirculatory parameters assessed by Near Infrared Spectroscopy; CRP, IL-2, IL-6, IL-10 VEGF levels measured plasma.
 Results: Cardiopulmonary microcirculatory indices improved rehabilitation. CRP IL-6/IL-10 ratio decreased By linear regression analysis, negative correlation was noted between IL-6 changes (post-CPET values) VE/VCO2 slope change, entire cohort. separately maintained only COM group.
 Conclusions: Overall, results reinforce view an anti-inflammatory patients. significant correlations demonstrated cytokine responses ventilatory response to exercise, particularly group, probably ensue from special training peripheral muscle function.